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. Author manuscript; available in PMC: 2015 Jan 3.
Published in final edited form as: J Proteome Res. 2013 Dec 6;13(1):137–146. doi: 10.1021/pr400792p

Figure 2.

Figure 2

Two representative mass spectrometry peak profiles that show the identification of two mutations in peptide sequences. (a) A peptide (GIQLVEEELDR) in tropomyosin beta chain (TPM2) differed by one amino acid identified in normal adult lung tissue from the known sequence of the TPM2 protein in databases. Arginine at position 91 was changed to glycine, likely due to a known SNP in the gene (rs104894127). (b) Based on mutations in the COSMIC database, a peptide (LLNRLADLVER) derived from the gene aldehyde dehydrogenase X, mitochondrial (ALDH1B1) was identified by a mutant-specific database search. A single amino acid substitution, arginine at position 107 to leucine, was identified from the database sequence.