Table 2.
Overall hazard ratios for each endpoint per one SD increase in mean common carotid artery intima-media thickness in four models
| Yearly carotid intima-media
thickness progression |
Mean carotid intima-media
thickness of scans 1 and 2 |
|||
|---|---|---|---|---|
| Overall HR (95% CI) | I2 (p)* | Overall HR (95% CI) | I2 (p)* | |
|
Myocardial
infarction†
| ||||
| Model 1 | 0·99 (0·94–1·04) | 0·0% (0·9216) | .. | .. |
| Model 2 | 0·96 (0·92–1·01) | 0·0% (0·9857) | 1·30 (1·19–1·43) | 57·5% (0·0067) |
| Model 3 | 0·96 (0·92–1·01) | 0·0% (0·9831) | 1·30 (1·19–1·43) | 56·9% (0·0076) |
| Model 4 | 0·97 (0·92–1·02) | 0·0% (0·9841) | 1·22 (1·14–1·30) | 21·6% (0·2302) |
|
| ||||
|
Stroke‡
| ||||
| Model 1 | 1·01 (0·96–1·07) | 0·0% (0·7598) | .. | .. |
| Model 2 | 0·99 (0·95–1·04) | 0·0% (0·5969) | 1·32 (1·19–1·48) | 67·0% (0·0005) |
| Model 3 | 0·99 (0·95–1·05) | 0·0% (0·5933) | 1·32 (1·20–1·45) | 54·1% (0·0128) |
| Model 4 | 1·00 (0·95–1·05) | 0·0% (0·5134) | 1·21 (1·09–1·35) | 57·5% (0·0068) |
|
| ||||
|
Combined§
| ||||
| Model 1 | 0·99 (0·96–1·03) | 16·0% (0·2832) | .. | .. |
| Model 2 | 0·97 (0·94–1·00) | 0·0% (0·5583) | 1·24 (1·16–1·32) | 70·5% (<0·0001) |
| Model 3 | 0·97 (0·94–1·00) | 0·0% (0·5588) | 1·23 (1·17–1·31) | 60·3% (0·0026) |
| Model 4 | 0·98 (0·95–1·01) | 0·0% (0·7114) | 1·16 (1·10–1·22) | 47·4% (0·0294) |
|
| ||||
|
Death¶
| ||||
| Model 1 | 1·00 (0·97–1·03) | 0·0% (0·5991) | .. | .. |
| Model 2 | 0·98 (0·95–1·01) | 0·0% (0·9886) | 1·15 (1·08–1·22) | 60·7% (0·0012) |
| Model 3 | 0·98 (0·95–1·01) | 0·0% (0·9859) | 1·15 (1·09–1·21) | 44·5% (0·0325) |
| Model 4 | 0·99 (0·96–1·02) | 0·0% (0·9996) | 1·10 (1·05–1·16) | 36·8% (0·0754) |
p value of test for heterogeneity.
Studies included: Atherosclerosis and Insulin Resistance study; Atherosclerosis Risk in Communities Study; Carotid Atherosclerosis Progression Study; Cardiovascular Health Study, cohorts 1 and 2; Edinburgh Artery Study; Interventionsprojekt zerebrovaskuläre Erkrankungen und Demenz im Landkreis Ebersberg; Kuopio Ischemic Heart Disease Study; Progression of Lesions in the Intima of the Carotid; Rotterdam; Study of Health in Pomerania; Tromsø Study.
Studies included: Atherosclerosis Risk in Communities Study; Carotid Atherosclerosis Progression Study; Cardiovascular Health Study, cohorts 1 and 2; Edinburgh Artery Study; Interventionsprojekt zerebrovaskuläre Erkrankungen und Demenz im Landkreis Ebersberg; Kuopio Ischemic Heart Disease Study; Northern Manhattan Study/Infections and Vascular Disease Epidemiology Study; Progression of Lesions in the Intima of the Carotid; Rotterdam Study; Study of Health in Pomerania; Tromsø Study.
Studies included: Atherosclerosis and Insulin Resistance study; Atherosclerosis Risk in Communities Study; Carotid Atherosclerosis Progression Study; Cardiovascular Health Study, cohorts 1 and 2; Edinburgh Artery Study; Interventionsprojekt zerebrovaskuläre Erkrankungen und Demenz im Landkreis Ebersberg; Kuopio Ischemic Heart Disease Study; Northern Manhattan Study/Infections and Vascular Disease Epidemiology Study; Progression of Lesions in the Intima of the Carotid; Rotterdam Study; Tromsø Study.
Studies included: Atherosclerosis and Insulin Resistance study; Atherosclerosis Risk in Communities Study; Carotid Atherosclerosis Progression Study; Cardiovascular Health Study, cohorts 1 and 2; Edinburgh Artery Study; Etude sur le vieillissement artériel; Interventionsprojekt zerebrovaskuläre Erkrankungen und Demenz im Landkreis Ebersberg; Kuopio Ischemic Heart Disease Study; Northern Manhattan Study/Infections and Vascular Disease Epidemiology Study; Prospective Investigation of the Vasculature in Uppsala Seniors; Progression of Lesions in the Intima of the Carotid; Rotterdam Study; Study of Health in Pomerania; Tromsø Study.