Figure 2.
The effects of CMS on anxiety-like behavior. (A) Open arm time in the EPM. (B) The percent of open arm entries (out of all arm entries). (C)Total distance travelled in the EPM. (D) Total distance travelled in the NOF. (E) Percent distance in the center in the NOF test. (F) Time spent in the center of the NOF. N = 10 per group for A-C and N = 10 per group for D-F. * denotes main effect of sex by three-way ANOVA (p < 0.05). ^ denotes main effect of CMS by three-way ANOVA (p < 0.05). Significant stress by sex and sex by genotype interactions by three-way ANOVA were observed in C. A significant three-way sex by stress by genotype interaction was observed in E.