Figure 2.

The effects of presynaptic expression of mt-htau on homosynaptic depression kinetics, 5HT induced facilitation of the depressed synapse and the rescue of mt-htau-induced synaptic functions by paclitaxel. All recordings were made on day 6 in culture. (A) Raw average data. (B) Normalized results. Blue- control neurons. Red- mt-htau expressing presynaptic neurons for 3 days (days 4–6). Green- synaptic pairs bathed from day 4 to 6 in 10 nM paclitaxel. Magenta- synaptic pairs that express presynaptic mt-htau and cultured in the presence of paclitaxel from day 4 to 6. Arrowhead- time of 5HT application.