Table 1.
Electrophysiology parameters of the pre- and postsynaptic neurons.
Control | mt-htau | mt-htau & Paclitaxel | Paclitaxel | |
---|---|---|---|---|
Presynaptic resting | −40.87 ± 2.43 | −38 ± 2.37 | −42 ± 1.24 | −37.5 ± 1.34 |
potential (mV) | n = 8 | n = 6, p = 0.41 | n = 9, p = 0.69 | n = 8, p = 0.25 |
Postsynaptic (L7) | −53.91 ± 0.8 | −56.88 ± 1.61 | ||
resting potential (mV) | n = 11 | n = 16, p = 0.11 | ||
Presynaptic Input | 54.57 ± 5.54 | 57.37 ± 8.21 | 71.69 ± 13.62 | 72.73 ± 17.33 |
resistance (MΩ) | n = 12 | n = 8, p = 0.78 | n = 7, p = 0.28 | n = 6, p = 0.35 |
Postsynaptic (L7) | 26.67 ± 4.96 | 19.8 ± 1.62 | ||
Input resistance (MΩ) | n = 7 | n = 12, p = 0.29 | ||
Miniature potential | 0.22 ± 0.02, | 0.22 ± 0.03, | ||
amplitude (mV) | n = 205, 5 cells | n = 119, 6 cells | ||
Presynaptic spike | 97.12 ± 1.66, | 93.38 ± 2.08, | 93.51 ± 3.38, | 92.46 ± 6.73, |
amplitude (mV) | n = 8 | n = 8, p = 0.18 | n = 9, p = 0.36 | n = 4, p = 0.29 |
Presynaptic spike | 2.59 ± 0.09 | 2.37 ± 0.13 | 2.37 ± 0.18 | 2.39 ± 0.2 |
duration (msec) | n = 14 | n = 8, p = 0.22 | n = 9, p = 0.31 | n = 7, p = 0.39 |
Calcium peak (ΔF/F0) | 0.65 ± 0.07 | 0.79 ± 0.04 | 1.17 ± 0.22 | 0.66 ± 0.12 |
Presynaptic neuron | n = 6 | n = 5, p = 0.11 | n = 5, p = 0.08 | n = 7, p = 0.87 |