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. 2014 Feb 10;6:10. doi: 10.3389/fnagi.2014.00010

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Copyright © 2014 Zhao, Gu, Dai, Liu, Iqbal, Liu and Gong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Morris water maze tests of mice with CCH. Spatial memory of the mice was tested in the Morris water maze test (A–D) and the consecutive reversal test (E–L). The average swim speed in the training phase (A,E), the distance traveled to the hidden platform during training (B,F), the number of the platform site crossings during the probe trial (C,G), the percentage of distance traveled in the target, adjacent left (Adj.L), adjacent right (Adj.R), and opposite (Opp) quadrants during probe trial (D,H) and the gradual reduction in percent time/distance in the quadrant of previous platform and the gradual shift to the new quadrant (I–L) are shown. Data are reported as mean ± SEM.*p < 0.05 vs. sham mice.