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. 2014 Feb 10;6:10. doi: 10.3389/fnagi.2014.00010

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Copyright © 2014 Zhao, Gu, Dai, Liu, Iqbal, Liu and Gong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of CCH on O-GlcNAcylation and tau phosphorylation. Homogenates of the cortices and hippocampi of mice 2.5 months after sham or UCCAO surgery were analyzed by immuno-dot blots developed with a mixture of monoclonal antibodies RL2 and CTD110.6 against O-GlcNAcylated proteins and Western blots developed with the indicated antibodies (A,C). The blots were then quantified densitometrically, and the data after normalization with the GAPDH (B) or R134d for total tau level (D) are presented as mean ± SEM (n = 6/group), where the values of the sham group are set as 1.0.*p < 0.05 vs. sham group.