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. 2014 Feb 10;6:10. doi: 10.3389/fnagi.2014.00010

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Copyright © 2014 Zhao, Gu, Dai, Liu, Iqbal, Liu and Gong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of CCH on neuronal degeneration. Representative microphotographs of Fluoro-Jade stainining of cerebral cortex and dentate gyrus sections of mice 2.5 months after sham or UCCAO surgery (A). The Fluoro-Jade positive neurons were then quantified by using the Image J software, and the data are presented as mean ± SEM (n = 6/group) (B). Coexistence of hyperphosphorylated tau (detected using antibody against pS262) and Fluoro-Jade positive neurons was seen in adjacent sections (C).*p < 0.05 vs. sham group.