Table 1.
Initial clinical characteristics of the study group (N = 102)—median values and 1–3 quartiles.
| Control group (N = 29) |
Sepsis (N = 51) |
Severe sepsis (N = 22) |
|
|---|---|---|---|
| Gender (m/f) | 13/16 | 30/21 | 17/5* |
| Cesarean section (N (%)) | 11 (38%) | 24 (47%) | 10 (45%) |
| Gestational age (wks) | 39 (37–39) | 39 (38–40) | 38 (36–40) |
| Births weight (g) | 3150 (2850–3460) | 3330 (2900–3570) | 3110 (2610–3490) |
| Births length (cm) | 53 (51–54) | 54 (51–56) | 52 (50–55) |
| Apgar 1 min (pts) | 9 (9-10) | 10 (7–10) | 9 (7–10) |
| Apgar 5 min (pts) | 10 (9-10) | 10 (8–10) | 9.5 (8–10) |
| Day of life (d) | 6 (3–14) | 7 (2–17) | 9.5 (5–13) |
| Duration of hospitalization (d) | 16 (12–21) | 21 (17–25) | 20 (17–23) |
| NTIS score (pts) | 3 (2–5) | 7 (4–9)∧ | 21 (12–29)∧ |
| Leucocytes (109/L) | 11.2 (9.8–12.4) | 15.0 (11.9–18.5)∧ | 13.5 (7.1–20.6) |
| Thrombocytes (106/L) | 267 (185–326) | 266 (204–314) | 165 (100–271)** |
| PCT (ng/mL) | 0.13 (0.09–0.18) | 1.82 (0.22–7.09)∧ | 10.60 (2.22–56.38)∧ |
| CRP (mg/dL) | 0.5 (0.2–1.0) | 9.0 (1.1–42.0)∧ | 54.0 (36.0–100.5)∧ |
| Creatinine (mg/dL) | 0.79 (0.63–0.92) | 0.76 (0.48–0.99) | 0.85 (0.63–1.07) |
| eGFR (mL/min) | 29.6 (27.8–37.9) | 32.5 (24.8–51.1) | 24.1 (21.1–44.1) |
| Cystatin C (mg/L) | 1.72 (1.57–2.10) | 1.54 (1.46–1.85) | 1.65 (1.31–2.03) |
| Urinary output (mL/kg/h) | 1.0 (0.8–1.3) | 1.4 (1.2–1.6)* | 1.4 (1.1–1.7) |
| AKI (N (%)) | 0 | 3 (5.9) | 2 (9.1) |
| Urinary albuminin (mg/dL) | 23.4 (15.4–47.7) | 40.1 (29.2–56.8) | 35.7 (26.1–48.8) |
| Serum NGAL (ng/mL) | 69.7 (39.6–119.4) | 153.5 (71.4–267.8)∧ | 228.6 (72.6–508.6)∧ |
| Urinary NGAL (ng/mL) | 20.6 (10.2–37.1) | 59.0 (30.5–198.7)∧ | 131.2 (29.9–457.0)∧ |
| Urinary/serum NGAL | 0.30 (0.13–0.51) | 0.37 (0.20–0.93) | 0.50 (0.22–1.39) |
Statistical significance versus control group. *P < 0.05; **P < 0.01; ∧ P < 0.001.