Table 3.
Serum and urinary NGAL levels in septic newborns with and without urinary tract infections on the following time points. Mean value, 95% CI, and statistical significance of differences between the subgroups (U Mann-Whitney test) are presented, together with intragroup changes (ANOVA test).
| Urinary tract infection (N = 17) |
Septic patients without UTI (N = 54) |
P | |
|---|---|---|---|
| sNGAL (ng/dL) | |||
| Initial | 188.6 (102.1–275.0) | 246.4 (192.0–300.7) | NS |
| After 24 hours | 250.5 (108.8–392.3) | 232.5 (178.9–286.1) | NS |
| After 48 hours | 170.3 (76.8–263.8) | 164.1 (119.7–208.6) | NS |
| ANOVA | NS | P < 0.001 | |
|
| |||
| uNGAL (ng/dL) | |||
| Initial | 250.5 (108.8–392.3) | 158.2 (91.0–225.4) | 0.001 |
| After 24 hours | 275.7 (150.5–401.0) | 126.7 (68.6–184.7) | 0.003 |
| After 48 hours | 189.8 (69.5–310.2) | 108.3 (58.5–158.2) | NS |
| ANOVA | 0.07 | NS | |
|
| |||
| uNGAL/sNGAL ratio | |||
| Initial | 4.35 (0.53–8.18) | 0.59 (0.34–0.85) | <0.001 |
| After 24 hours | 2.58 (0.98–3.77) | 0.52 (0.38–0.67) | <0.001 |
| After 48 hours | 1.07 (0.66–1.49) | 0.66 (0.44–0.88) | 0.04 |
| ANOVA | NS | NS | |