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. 2014 Jan 21;2014:196169. doi: 10.1155/2014/196169

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Copyright © 2014 Yongxin Yu et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Genome map of norovirus (NoV; X86557). The NoV genome is composed of 3 open reading frames (ORFs). ORF1 (~5 kb) encodes the nonstructural proteins of an NTPase, 3C-like protease, and RNA-dependent RNA polymerase (RdRp). ORF2 is 1.8 kb in length and encodes the 57 kDa major structural capsid protein of viral protein 1 (VP1). VP1 is divided into the shell domain (S) and the protruding domain (P). The P domain contains two subdomains, known as P1 and P2. The regions of A, B, C, D, and E on NoV genome are used for genotyping. ORF3 encodes a minor structural protein VP2.