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. Author manuscript; available in PMC: 2014 Feb 10.
Published in final edited form as: Dev Cell. 2003 Jul;5(1):45–57. doi: 10.1016/s1534-5807(03)00169-2

Figure 5. Sema-Npn-1 Signaling Is Required for Growth of Basal Dendrites, but Not for Apical Dendrite Orientation.

Figure 5

(A and F) Orientation of apical dendrites of layer 5 pyramidal neurons from neocortex of P2 mutant (npn-1Sema−;thy1-YFP) (F) and control littermates (+/+;thy1-YFP) (A).

(B and G) Similar dendritic morphologies of cingulate cortical neurons from P14 mutant (npn-1Sema−;thy1-GFP-m) (G) and control littermates (+/+;thy1-GFP-m) (B).

(C–E and H–J) Dendritic morphologies of individual GFP-positive pyramidal neurons from P14 mutant (npn-1Sema−;thy1-GFP-m) (H–J) and control littermates (+/+;thy1-GFP-m) (C–E). While apical dendrite and axon orientation appears similar in mutants (H–J) and littermate controls (C–E), basal dendrites are less elaborate in mutants (H–J) compared to controls (C–E). Scale bar: 50 μm.