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. 2014 Jan 21;111(5):2005–2010. doi: 10.1073/pnas.1319703111

Fig. 3.

Fig. 3.

PARP-1 controls behavioral responses to cocaine. (A) Locomotor response to cocaine (5 mg/kg i.p.) in mice injected intra-NAc with HSV-GFP or HSV-PARP-1. (B) Conditioned place preference for cocaine in mice injected intra-NAc with HSV-GFP or HSV-PARP-1. (C) Number of self-administered infusions of cocaine by rats, trained to self-administer cocaine and then injected intra-NAc with HSV-GFP or HSV-PARP-1, and tested 2–5 d later for self-administering elevating intravenous cocaine doses. (D) Locomotor responses to cocaine in mice with intra-NAc infusion of TIQ-A or vehicle. (E) Conditioned place preference for cocaine in mice injected intra-NAc with HSV-GFP or HSV-PARG. Data are presented as mean ± SEM (n = 7–10). *P < 0.05.