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Comparison of surface electrostatic potentials of different propellers. Surface electrostatic potentials of the Dos1WD putative target-binding site, DDB2 DNA-binding site (PDB ID code 4A0K), Fbw7 phospho-peptide–binding site (PDB ID code 3V7D), Sif2p (PDB ID code 1R5M), and WDR5 (PDB ID code 3UVN) were compared. Surface electrostatic potentials were calculated using the APBS plugin in Pymol and mapped onto the solvent-accessible surface of the proteins (contoured from −5 to +5 eV) (49).
