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PhoQcHAMP activates pag expression and antimicrobial peptide resistance more than other constitutively activated PhoQ enzymes. (A) A phoN reporter measured pag activation in phoQ deletion mutants expressing phoQ alleles in trans. (B) Bacteriocidal activity of C18G against S. Typhimurium phoQ deletion mutants expressing vector alone (●), phoQWT (▲), phoQT48I (◆), phoQcHAMP (■). (C) Antimicrobial activity of polymyxin B against bacteria on solid media.
