Table 3.

Model parameter values.

Glossary		Central SAN model	Peripheral SAN model
C m	Cell membrane capacitance	20 pF	65 pF
g Na	Maximum i Na conductance	0 μS/pF	1.85 × 10−8 μS/pF
g K,Ach,max	Maximum i K,Ach conductance	3.53 × 10−10  μS/pF	1.218 × 10−9 μS/pF
g Ca,L	Maximum i Ca,L conductance	2.9 × 10−4  μS/pF	1.0 × 10−3 μS/pF
g f,Na	Maximum i f,Na conductance	0.27 × 10−4  μS/pF	1.05 × 10−4 μS/pF
g f,K	Maximum i f,K conductance	0.27 × 10−4  μS/pF	1.05 × 10−4 μS/pF
g K,r	Maximum i K,r conductance	3.99 × 10−5  μS/pF	2.46 × 10−4 μS/pF
g K,s	Maximum i K,s conductance	2.59 × 10−5  μS/pF	1.6 × 10−4 μS/pF
g st	Maximum i st conductance	0.75 × 10−5  μS/pF	0 μS/pF
E Ca,L	Apparent reversal potential for i Ca,L	46.4 mV	46.4 mV
E st	Apparent reversal potential for i st	37.4 mV	37.4 mV
[Na+]o	Extracellular Na+ concentration	140 mM	140 mM
[K+]o	Extracellular K+ concentration	5.4 mM	5.4 mM
K 0.5,K,Ach	[Ach] that produces a half-maximal activation of g K,Ach,max	0.28 μM	0.28 μM
K 0.5,Ca	[Ach] that produces a half-maximal block of i Ca,L	0.09 μM	0.09 μM
K 0.5,Ca′	[Iso] that produces a half-maximal increase of i Ca,L	7 nM	7 nM
K 0.5,f	[Ach] that produces a half-maximal shift of i f activation curve	1.26 × 10−2  μM	1.26 × 10−2  μM
K 0.5,f′	[Iso] that produces a half-maximal shift of i f activation curve	13.5 nM	13.5 nM
K 0.5,gK	[Iso] that produces a half-maximal increase of g K,r	19 nM	19 nM
K 0.5,Kacti	[Iso] that produces a half-maximal shift of i K,r activation curve	7.5 nM	7.5 nM
K 0.5,τK,r	[Iso] that produces a half-maximal decrease of τK,r	24 nM	24 nM
K 0.5,st	[Iso] that produces a half-maximal Increase of i st	33 nM	33 nM
P up	Rate constant of Ca2+ uptake by j up of the network SR	0.01 mM/ms	0.02 mM/ms
n K,Ach	i K,Ach affected by [Ach] and Hill coefficient	1.5	1.5
n f	i f affected by [Ach] and Hill coefficient	0.69	0.69
n up	SR Ca2+ uptake and Hill coefficient	2	2
n f′	i f affected by [Iso] and Hill coefficient	0.392	0.392
S Na	Percentage change of i Na conductance induced by DelF1617 mutation	0.38	0.38
S τh1	Percentage change of the fast-inactivation time constants of i Na induced by DelF1617 mutation	2.18	2.18
S τh2	Percentage change of the slow-inactivation time constants of i Na induced by DelF1617 mutation	2.75	2.75
S h	Parameter of the shift in the inactivation curve of i Na induced by DelF1617 mutation	0.128	0.128
b max⁡	Maximum fraction of i Ca,L block caused by Ach	0.56	0.56
s max⁡	Maximum shift of i f activation curve caused by Ach	−7.2 mV	−7.2 mV
f Ca,max⁡	Maximum percentage increase of i Ca,L caused by Iso	0.54	0.54
f K,max⁡	Maximum percentage increase of i K,r caused by Iso	1.87	1.87
f st.max	Maximum percentage increase of i st caused by Iso	1.0	1.0
S f,max	Maximum activation curve shift of i f caused by Iso	9.62 mV	9.62 mV
S K,max⁡	Maximum activation curve shift of i K,r caused by Iso	−15 mV	−15 mV
d τK,r,max⁡	Maximum decrease of τK,r, caused by Iso	3.0	3.0
αIso	Percentage increase of the SR Ca2+ release fluxes caused by Iso	0.2	0.2
βIso	Percentage decrease of the SR Ca2+ uptake caused by Iso	0.2	0.2