Table 3.
The relative numbers of angiotensin II AT1 receptor subtypes in the renin-negative and renin-positive SMCs in STZ-induced diabetic and normal rat kidney arterioles. The normal state in the number of AT1-B receptors between the renin-negative and renin-positive SMCs is changed to significantly different in diabetes, because of the enhanced downregulation of the AT1-B receptors in renin-positive SMCs.
| n | Renin-positive SMCs | Renin-negative SMCs | Difference | P | ||
|---|---|---|---|---|---|---|
| Mean (CV) | ||||||
| Angiotensin II AT1-A receptors in afferent arterioles cells surface (signals/um3) | Normal | 4 | 0.133 (0.42) | 0.215 (0.18) | 38% | 0.026 |
| Angiotensin II AT1-B receptors in afferent arterioles cells surface (signals/um3) | Normal | 4 | 0.203 (0.34) | 0.176 (0.11) | 13.3% | NS |
| Angiotensin II AT1-A receptors in afferent arterioles cells surface (signals/um3) | Diabetic | 5 | 0.0345 (0.52) | 0.058 (0.31) | 41% | 0.035 |
| Angiotensin II AT1-B receptors in afferent arterioles cells surface (signals/um3) | Diabetic | 5 | 0.033 (0.45) | 0.055 (0.16) | 40% | 0.0096 |
| Angiotensin II AT1-(A + B) receptors in afferent arterioles cells surface (signals/um3) | Normal | 4 | 0.156 (0.27) | 0.216 (0.18) | 27.8% | 0.043 |
| Angiotensin II AT1-(A + B) receptors in afferent arterioles cells surface (signals/um3) | Diabetic | 5 | 0.035 (0.30) | 0.057 (0.38) | 37.8% | 0.041 |