FIGURE 2.
Individually, engagement of CD19 or CD32b differentially regulates B cell responses depending on the context of the stimulation. Purified peripheral blood B cells were isolated from healthy donors and stimulated with IL-21/anti-CD40/anti-IgM or CpG-B in the presence of isotype control, anti-CD19, or anti-CD32b Abs. (A) Expansion was quantified on day 4. (B and C) PC differentiation was quantified on day 7. Frequency (B) and absolute number (C) of IgD− CD38hi PCs are indicated. One of five representative donors is shown. *p < 0.05, **p < 0.01, ***p < 0.005.