Table 4.

Regression analyses for prediction of shoulder pain phenotypes by genetic and psychological factors

Model Description	R-Square Increment					R-Square Full Model	p-value Full Model
Model Description	Age, Sex, and Race	Add Genotype	Add Psychological Factor	Add Interaction Term	P-value Interaction Term	R-Square Full Model	p-value Full Model
*Prediction of 5-Day Average Pain Intensity*
Age, sex, and race + COMT + PHQ + COMT*PHQ	0.034	0.047^{^}	0.043	0.084	0.0105	0.208	0.003
*Prediction of Peak Pain Intensity*
Age, sex, and race + ADRB2 + TSK + ADRB2*TSK	0.054^{^}	0.007	0.054	0.037	0.0182	0.152	0.022
*Prediction of 5-Day Average Upper Extremity Disability*
Age, sex, and race + COMT+ PCS + COMT*PCS	0.078^{^}	0.038^{^}	0.140^{^}	0.091	0.0011	0.347	<0.0005
Age, sex, and race + COMT+ PHQ + COMT*PHQ		0.115^{^}	0.039^{^}	0.140	0.0299	0.295	<0.0005
Age, sex, and race + KCNS1 (rs734784) + PCS + KCNS1 (rs734784)*PCS		0.079	0.062^{^}	0.123	0.0108	0.342	<0.0005
*Prediction of Peak Upper Extremity Disability*
Age, sex, and race + COMT+ PCS + COMT*PCS	0.063^{^}	0.025^{^}	0.098^{^}	0.070	0.0043	0.256	<0.0005
Age, sex, and race + KCNS1 (rs734784) + PCS + KCNS1 (rs734784) *PCS		0.066	0.038^{^}	0.104	0.0259	0.208	0.002
*Prediction of Shoulder Pain Duration*
Age, sex, and race + COMT+ PHQ + COMT* PHQ	0.033	0.000	0.052	0.068	0.0010	0.153	0.008
Age, sex, and race + COMT+ TSK + COMT*TSK		0.000	0.001	0.077	0.0094	0.111	0.099
Age, sex, and race + ADRB2 + PHQ + ADRB2 *PHQ		0.060^{^}	0.015	0.097	0.0153	0.205	0.014
Age, sex, and race + AVPR1 (rs1042615) + PHQ + AVPR1 (rs1042615) *PHQ		0.045	0.020	0.108	0.0065	0.206	0.016
Age, sex, and race + AVPR1 (rs10877969) + PHQ + AVPR1 (rs10877969)*PHQ		0.043	0.017	0.106	0.0069	0.199	0.021
Age, sex, and race + AVPR1 (rs10877969) + PCS + AVPR1 (rs10877969)*PCS		0.043	0.004	0.088	0.0314	0.168	0.113

Models in bold font meet criterion for strong statistical evidence of interaction term;

^{^}

indicates p-valued for R-Square main effect is < 0.05;

Gene without rs number is the associated diplotype; PHQ - Patient Health Questionnaire (depressive symptoms); PCS – Pain Catastrophizing Scale, TSK – Tampa Scale of Kinesiophobia;