Figure 4. Recognition of endogenously expressed variant epitopes.
ELR_MYM/ELK_IYM (a), ELR_MYM (b) or ELK_IYM (c & d) specific T cells were incubated for five hours with HLA B8+ fibroblasts infected with the ELR_MYM encoding Merlin or ELK_IYM encoding TB40E strains. IFN-γ expression was then assessed using an intracellular cytokine assay. Data represents the proportion of ELR_MYM or ELK_IYM specific CD8+ T cells recognising the CMV-infected cells at the indicated responder to stimulator ratio.
