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. 2014 Feb 10;4:3993. doi: 10.1038/srep03993

Figure 7. Structural changes associated with the P6-P8 residues of the IE-1 epitope variants in complex with the HLA B8 molecule.

Figure 7

(a) The panels represent a superposition of the three peptide-HLA B8 structures, with the HLA B8 molecules represented in cartoon and the peptide coloured in blue for ELR_MYM, in green for ELK_IYM and pink for ELN_IYM. The spheres represent the Cα atom of the P6 residue on the peptides and of the Ala150, Arg151, Val152, Thr69 and Thr73 on the HLA B8 molecules. The blue dashed lines represent the atomic interaction between the peptide residues and the HLA B8 residues. (b) The panel shows the structural difference in the peptides at position P7 and P8, with the peptides coloured according to panel A, and the blue dashed line represents the interaction between the P7 and P8 residues of the ELR_MYM peptide.