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. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: Diabetologia. 2013 May 28;56(9):1964–1970. doi: 10.1007/s00125-013-2951-8

Figure 1. Diabetes-free survival according to HLA-B*18, HLA-B*39 or HLA-A*24 status in 288 persistently Ab+ FDRs with or without stratification according to the presence or absence of HLA-DQ8 or HLA-DQ2.

Figure 1

(a) Whole group (n = 288) with (solid line) vs without (dashed line) HLA-B*18 (p = 0.021). (b) Whole group (n = 288) with (solid line) vs without (dashed line) HLA-B*39 (p = 0.377). (c) HLA-DQ8-positive (n = 174) relatives with (solid line) vs without (dashed line) HLA-A*24 (p = 0.002). (d) HLA-DQ8-negative relatives (n = 114) with (solid line) vs without (dashed line) HLA-A*24 (p = 0.750). (e) HLA-DQ2-positive (n = 145) relatives with (solid line) vs without (dashed line) HLA-B*18 (p = 0.005). (f) HLA-DQ2-negative relatives (n = 143) with (solid line) vs without (dashed line) HLA-B*18 (p = 0.277). The numbers given for each arm are number of events (total number at study entry). For the number of relatives under follow-up at different time points, see ESM Table 3. p by logrank test.