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. Author manuscript; available in PMC: 2014 Aug 1.
Published in final edited form as: Curr Opin Lipidol. 2013 Aug;24(4):345–350. doi: 10.1097/MOL.0b013e3283616364

Figure 1. Summary of potential “beneficial effects” of n-3 FA in atherosclerosis.

Figure 1

n-3 FA modulate atherosclerosis by affecting uptake and binding of LDL to the arterial wall. This is associated with reduced arterial LpL and macrophage levels. n-3 FA are protective against inflammation in the arterial wall by reducing the production of pro-inflammatory cytokines in monocytes (MO), macrophages or dendritic cells (DC) and decreasing the recruitment of inflammatory leukocytes to the arterial wall, including neutrophils (NE) and MO. Lastly, n-3 FA and n-3-derived eicosanoids, resolvins and protectins are potential anti-inflammatory lipid mediators in atherosclerosis. Specific examples of pathways related to each area are shown in the square boxes.