Table 1.
Phenotype* | Genotype DL/DL | +/+ and DL/+ and Ptch1-LacZ/+ | DL/Ptch1-LacZ |
---|---|---|---|
Dead | 0 | 0 | 17 |
Exencephaly | 0 | 0 | 34 |
Skull vault hypoplasia | 100 | 0 | 100 |
Lambdoid suture synostosis | 100 | 0 | 100# |
Narrow basisphenoid | 100 | 0 | 100 |
Missing presphenoid | 100 | 0 | 100 |
Hypoplastic alisphenoid | 100 | 0 | 100 |
Hypoplastic palatal shelves | 100 | 0 | 100 |
Coronoid hypoplastic | 37.5 | 0 | 100 |
Kinked Tail | 0 | 0 | 34 |
Abnormal sternum | 100 | 0 | 100$ |
Defective scapulas | 12.5 | 0 | 50 |
Affected forelimbs | 100 | 0 | 100 |
Affected hindlimbs | 100 | 0 | 78 |
Numbers represent the percentage of a particular genotype showing an abnormal phenotype for the structure described.
Lambdoid suture synostosis was only scored in DL/Ptch1-LacZ embryos that underwent normal neural tube closure and had sufficient development of the calvaria for visualization.
Bifurcated and fused ribs occur in association with sternal defects in some embryos.