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Figure 1. Regulation of Rb family members by CTSL. Blots showing that overexpression of CTSL via retroviral transduction of wild-type MEFs leads to downregulation of the pocket proteins pRb and p107 but has no effect in the levels of p130. As a control for increased CTSL activity, we show decreased levels of 53BP1 in the CTSL overexpressing cells.
