Table 1. The comparative induction of Wnt activation produced by HDACi inhibitors in HCT-R and parental HCT-116 cells.
| TOP/FOP Ratioa, 24 hr treatment | ||||||
|---|---|---|---|---|---|---|
| CELLS | CTRL±Db | NaB | TSA | CTRL+Mc | MS275 | SAHA |
| HCT-R | 2.1±0.9 | 7.0±1.2 (3 ×) | 13.9±6.1 (7 ×) | 5.6±1.5 | 13.6±2.5 (2.4 ×) | 24.8±1.7 (4.4×) |
| HCT-116 | 3.2±0.8 | 114.1±20.3 (36 ×) | 128.0±11.9 (40 ×) | 6.4±1.5 | 105.7±9.2 (16 ×) | 176.6±16.8 (28 ×) |
a
TOP/FOP ratio following exposure for 24 hr to HDACis (5 mM NaB, 1μM TSA, 10 μM MS275, 10 μM SAHA).
b
DMSO vehicle control.
c
Methanol vehicle control.