Table III.
Loss of MMR Protein Expression (LoE) in Epithelial Ovarian Cancer Cases with TMA Slides
| Row Total, n |
LoE | No LoE | P-value | ||
|---|---|---|---|---|---|
| Proportions in TMA slides - n (%) | 340 | 61/340 (17.9) | 279/340 (82.1) | <0.001 | |
| Age - Mean (SD) | 340 | 56.4 (13.1) | 56.5 (11.8) | 0.927 | |
| Histology | |||||
| Borderline, n (%) | 39 | 6 (1.8) | 33 (9.7) | 0.821 | |
| Invasive, n (%) | 301 | 55 (16.2) | 246 (72.4) | ||
| Serous, n (%) | 178 | 24 (9.1) | 154 (58.1) | 0.003** | |
| Non-Serous, n (%) | 87 | 25 (9.4) | 62 (23.4) | ||
| Clear cell | 17 | 6 (6.9) | 11 (12.6) | 0.364 | |
| Endometriod | 52 | 12 (13.8) | 40 (46.0) | ||
| Mucinous | 18 | 7 (8.0) | 11 (12.6) | ||
| Other | 36 | 6 (16.7) | 30 (83.3) | - | |
| Family History | |||||
| Relatives with Colorectal Cancer (CRC) | |||||
| # (%) of subjects with relatives with CRC | 64 | 14 (4.1) | 50 (14.7) | 0.466 | |
| # (%) of subjects with no relatives with CRC | 276 | 47 (13.8) | 229 (67.4) | ||
| Relatives with Endometrial Cancer (EC) | |||||
| # (%) of subjects with relatives with EC | 19 | 3 (0.9) | 16 (4.7) | 0.955* | |
| # (%) of subjects with no relatives with EC | 321 | 58 (17.1) | 263 (77.4) | ||
| Relatives with any HNPCC cancers | |||||
| # (%) of subjects with relatives with any HNPCC cancers | 116 | 23 (6.8) | 93 (27.4) | 0.544 | |
| # (%) of subjects with no relatives with any HNPCC cancers | 224 | 38 (11.2) | 186 (54.7) | ||
**
Test between Serous and Non Serous, excluding other.