Fig. 8.

Presentation of the VBM results produced by the SPM software with the SPMMouse plugin. From left to right, a maximum-intensity projection (MIP) of the results is shown in sagittal, coronal and horizontal sections; the design matrix for the study; and a coloured overlay showing the location of significant clusters. The colour bar refers to Student’s t-score with 8 degrees of freedom. Values shown indicate GM scores lower R6/2 mouse compared to WT control mice (p < 0.05, voxelwise FDR-corrected).