Table 2.
Summary of particular non-conserved amino acid replacements observed in recent Venezuelan isolates.
| Serotype | Proteins |
||||
|---|---|---|---|---|---|
| E | NS1 | NS2A | NS4B | NS5 | |
| DENV-1 | D146Ga | H18Ya | |||
| DENV-2 | I93Tb | A109Tb | S24Pc | ||
| T264Ic | Q164L/Ra,b | ||||
| DENV-3 | K4Ea | S229Ad | |||
| P365Sd | |||||
| K371Rd | |||||
| E374Gd | |||||
| R389Kd | |||||
| R422Kd | |||||
| E429Dd | |||||
| DENV-4 | A222Ta | D290Na | |||
| S354Aa | |||||
a
Amino acid replacements in Venezuelan isolates unusual for global sequences.
b
Amino acid replacements in recent Venezuelan isolates compared with previous circulating lineages.
c
Amino acid replacements in Venezuelan isolates from the same period (2006–2007).
d
Amino acid replacements in Latin American isolates compared with others isolates corresponding to genotype III.