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. Author manuscript; available in PMC: 2014 Feb 10.
Published in final edited form as: Science. 2012 Sep 21;337(6101):1532–1536. doi: 10.1126/science.1224151

Fig. 3.

Fig. 3

Behavior of dynamic salt bridges in the MTBD as determined by MD. (A) K3298 in H1 of the MTBD alternates between an intermolecular salt bridge with E420 on β-tubulin (MTBD-MT) and an intramolecular salt bridge with E3289 on CC1 of the MTBD (intra-MTBD). (B) R3382 in H6 of the MTBD alternates between an intermolecular salt bridge with E414 and E420 on α-tubulin (MTBD-MT) and an intramolecular salt bridge with E3378 in H6 (intra-MTBD). Single letter amino acid code and number are indicated for Bos taurus tubulin and Mus musculus cytoplasmic dynein. Time stamps for frames from MD simulations are indicated. Intermediate refers to a position midway between MTBD-MT and intra-MTBD salt bridges.