Fig. 2.

Investigating dose-dependent pain following bradykinin (BK) administration. (A) Pain ratings during iontophoresis of BK and saline vehicle. Displayed as average at each 20-second timepoint. (B) Area under the curve (AUC). Pain ratings during 8-minute iontophoresis compound administration. Results displayed as average n = 10 with SEM. ^∗∗∗P < 0.001, 2-way repeated-measures analysis of variance with Bonferroni post hoc analysis; n = 10. (C) Saline visual analogue scale (VAS) AUC data plotted at each dose to demonstrate any linearity with dose response; R² = 0.0334. (D) BK VAS AUC data plotted at each dose to demonstrate any linearity with dose response; R² = 0.9683.