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. 2013 Jun;154(6):782–792. doi: 10.1016/j.pain.2013.01.003

Fig. 5.

Fig. 5

Mast cell degranulation. (A) Mast cell degranulation by repeated iontophoretic application of compound 4880. Extent of mast cell degranulation indicated by size of flare outside of primary site. (B) Difference between pain ratings during iontophoresis of bradykinin (BK) and saline in both naïve and mast cell degranulated skin. (C) Area under the curve (AUC) for the difference between pain ratings as shown in (B); paired t-test; P = 0.02. Quantitative sensory testing following iontophoretic application of saline or BK in both naïve and mast cell degranulated skin. (D) Heat pain thresholds (HPT) naïve P < 0.001, degranulated P = 0.039. (E) Mechanical pain thresholds (MPT) naïve P < 0.001, degranulated P = 0.002. (F) Area of flare naïve P < 0.001, degranulated P = 0.035. A and C both use one-way analysis of variance with Bonferroni post hoc analysis.