Table 4.

Mendelian Conditions in which Major Depression Has Been Listed as a Phenotype

MIM	Name	Clinical Features	Prevalence	Inheritance	Gene
#168605	Perry sydrome	The earliest and most prominent symptom may be MD not responsive to antidepressant drugs or electroconvulsive therapy. Sleep disturbances, exhaustion, and marked weight loss are features.	Eight families in the world	Dominant	DCTN1
#314250	Dystonia 3, torsion, X-linked; DYT3	The odds ratio for overall MD was increased OR = 2.85, 95% CI = 0.56–5.14) in patients with DYT3 compared to the control group.	5.24 in 100,000 on Panay Island, Philippines	X-linked	TAF1
#128100	Dystonia 1, torsion, autosomal dominant; DYT1	Carriers of DYT1 are over four times more likely than noncarriers to exhibit recurrent MD. Relative risk of 3.62	In France, an estimated disease frequency of 0.13 in 100,000	Dominant	DYT1
#222300	Wolfram syndrome 1; WFS1	Additional clinical features include diverse psychiatric disorders	Heterozygous carriers of the Wolfram syndrome, estimated to represent approximately 1% of the United States population, are predisposed to MD.	Recessive	WFS1

The column headed MIM provides the reference number in Mendelian Inheritance in Man (http://www.omim.org).