. 2013 Aug;145(2):293–308. doi: 10.1053/j.gastro.2013.05.050

Table 2.

MicroRNA Studies in IBD in Peripheral Blood and Intestinal Biopsy Specimens

Authors	Subjects	Samples	Techniques	Increased microRNA expression	Decreased microRNA expression
Peripheral blood microRNA studies
Duttagupta et al, 2012¹²⁹	20 active UC vs 20 healthy controls	Peripheral blood	qRT-PCR	miR-188-5p, -378, -422a, -500, -501-5p, -769-5p, and -874
Paraskevi et al, 2012¹³⁰	128 CD vs 162 healthy controls	Peripheral blood	qRT-PCR	miR-16, -23a, -29a, 106a, -107, -126, -191, -199a-5p, -200c, 362-3p, and 532-3p
Paraskevi et al, 2012¹³⁰	88 active UC vs 162 healthy controls	Peripheral blood	qRT-PCR	miR-16, -21, -28-5p, -151-5p, -155, and 199a-5p
Wu et al, 2011¹¹⁴	14 active CD vs 13 healthy controls	Peripheral blood	Microarray and qRT-PCR	miR-199a-5p, -340, -363-3p, -532-3p, and miRplus-E1271	miR-149* and miRplus-F1065
	5 quiescent CD vs 13 healthy controls			miR-340*	miR149*
	13 active UC vs 13 healthy controls			miR-28-5p, -151-5p, -103-2, -199a-5p, -340, -362-3p, -532-3p, and miRplus-E1271	miR-505*
	10 active UC vs 10 active CD			miR-28-5p, 103-2, 149, 151-5p, -340, -532-3p, and miRplus-E1153	miR-505*
Zahm et al, 2011¹¹⁵	46 active CD vs 32 healthy controls	Serum	LDA qRT-PCR	miR-16, -20a, -21, -30e, -93, -106a, -140, -192, -195, -484, and let-7b
Colonic biopsy microRNA studies
Bian et al, 2011¹⁰⁹	5 active UC vs 4 healthy controls	Colonic biopsy specimens	qRT-PCR	miR-150
Brest et al, 2011¹¹³	83 active CD vs 67 healthy controls	Colonic biopsy specimens	qRT-PCR and in situ hybridization	miR 196
Fasseu et al, 2010¹¹¹	8 active UC vs 8 healthy controls	Colon biopsy specimens	qRT-PCR	miR-7, -31, -135b, 223, 29a, 29b, -126, -127-3p, and -324-3p	miR-188-5p, -215, -320a, and -346
	8 quiescent UC vs 8 healthy controls			miR-196a, -29a, 29b, -126, -127-3b, and -324-3p	miR-188-5p, -215, -320a, and 346
	8 active CD vs 8 healthy controls			miR-9, -21, -22, -26a, -29a, 29c, 30b, -31, -34c-5p, -106a, -126, -126*, -127-3p, -130a, -133b, -146a, -146b-3p, -150 ,155, -181c, -196a, -324-3p, -375
	8 quiescent CD vs 8 healthy controls			miR-9, -21, -22, -26a, 29b, 29c, 30a, -30b, -30c -31, -34c-5p, 106a, -126, -127-3p, -133b, -146a, 146b-3p, -150, -155, -196a -223, and -324-3p
	8 quiescent UC vs 8 quiescent CD				miR-150, 196b, -199a-3p, -199-5p, -223, and 320a
Nguyen et al, 2010¹⁵²	8 active CD vs 6 healthy controls	Colonic biopsy specimens	qRT-PCR		miR-7
Olaru et al, 2011¹⁵³	IBD-associated dysplasia vs active IBD	Colonic biopsy specimens	Microarray and qRT-PCR	miR-31, 31, -96, -135b, -141, -183, -192, -192, -194, -194, -200a, -200a, -200b, -200b, -200c, -203, -215, -224, -375, -424, -429, and -552	miR -122, -139-5p, -142-3p, -146b-5p, -155, -223, -490-3p, 501-5p, -892b, and -1288
Pekow et al, 2012¹⁵⁴	8 active UC vs 8 healthy controls	Colonic biopsy specimens	qRT-PCR		miR-143 and -145
Takagi et al, 2010¹¹⁰	12 active UC vs 12 healthy controls	Sigmoid colon biopsy	Microarray and qRT-PCR	miR-21 and -155
Wu et al, 2008¹⁰⁸	15 active UC vs 15 healthy controls	Sigmoid colon biopsy	Microarray and qRT-PCR	miR-16, -21, 23a, 24, 29a, 126, 195, and left-7f	miR-192, 375, and 422b
Wu et al, 2010¹¹²	5 active colonic CD vs 13 healthy controls	Sigmoid colon biopsy specimens	Microarray and qRT-PCR	miR-23b, -106a, and -191	miR-19b and -629
Wu et al, 2010¹¹²	6 active small bowel CD vs 13 healthy controls	Terminal ileal biopsy specimens	Microarray and qRT-PCR	miR-16, -21, -223, and 594

qRT-PCR, quantitative reverse-transcriptase polymerase chain reaction.