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Anisotropy and dynamics in human P2. (a) Alternative conformations in residues interacting with the fatty acid in the binding cavity. (b) Main-chain mean anisotropy along the human P2 sequence. A fully isotropic atom has an anisotropy of 1.0. (c) Atomistic simulation of apo (black) and liganded (red) P2 based on a 30 ns trajectory. The difference between the apo and liganded simulations is shown in green.
