Scheme 2. Synthesis of analogues 3–5, 8, 9, 12a.
a. Reagents and conditions: (a) Boc-L-Dmt, PyBOP or HATU, HOBt-Cl, DIEA, DMF; (b) TFA, DCM; (c) MsCl, Et3N, DCM, 0°C; (d) piperazine, THF, reflux.
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