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. Author manuscript; available in PMC: 2014 Feb 10.
Published in final edited form as: Biotechnol Bioeng. 2012 Dec 25;110(5):1456–1465. doi: 10.1002/bit.24795

Table I.

Pharmacokinetic parameters of the HIRMAb-ASA fusion protein

parameter units value
A1 %ID/mL 0.243 ± 0.034
A2 %ID/mL 0.018 ± 0.003
k1 min-1 0.185 ± 0.024
k2 min-1 0.010 ± 0.002
MRT min 59 ± 12
Vc mL/kg 46 ± 6
Vss mL/kg 233 ± 39
AUC|120 %ID·min/mL 2.57 ± 0.12
AUCss %ID·min/mL 3.10 ± 0.19
AUCss ug·min/mL 14.2 ± 0.8
CL mL/min/kg 3.9 ± 0.2

Parameters computed from the plasma profile in Figure 6.