Table 2.
Plasma concentrations of D2-nicotine, D2-nicotine-glucuronide, D2-cotinine, D2-cotinine-glucuronide, D2-3OH-cotinine, D0-nicotine D0-nicotine-glucuronide, D0-cotinine, D0-cotinine-glucuronide and D0-3OH-cotininea
| D2-nicotine | D2-nicotine-glucuronide | D2-cotinine | D2-cotinine-glucuronide | D2-3OH-cotinine | D0-nicotine | D0-nicotine-glucuronide | D0-cotinine | D0-cotinine-glucuronide | D0-3OH-cotinine | |
|---|---|---|---|---|---|---|---|---|---|---|
| All Subjects (192b/131c) | 5.1 ±3.5 | 3.9 ±2.3 | 136 ±37.4 | 4.6 ±2.6 | 13.7 ±8.9 | |||||
| Males (92/61) | 5.1 ±2.8 | 3.7 ±2.0 | 117±28.5* | 3.9 ±2.4 | 10.0 ±5.4 | |||||
| Females (100/70) | 5.2 ±4.1 | 4.2 ±2.6 | 152 ±36.5* | 5.1 ±2.6 | 17.0 ±10.0 | |||||
| Current smokersd | ||||||||||
| All (103/72) | 5.0 ±3.6 | 4.1 ±2.4** | 133 ±39.2 | 5.1 ±2.9*** | 13.9 ±9.4 | 186 ±86.5 | 30.9 ±31.2 | 1890 ±1080 | 87.9 ±68.6 | 558.3 ±349.8 |
| Male (53/32) | 4.6 ±2.8 | 4.0 ±2.1 | 115 ±29.0 | 4.8 ±2.8 | 10.8 ±6.2 | 196 ±93.6 | 36.1 ±39.5 | 2020 ±1180 | 95.8 ±80.8 | 579.3 ±388.8 |
| Female (50/40) | 5.4 ±4.3 | 4.4 ±2.7 | 150 ±40.4 | 5.4 ±3.0 | 17.1 ±11.0 | 175 ±77.7 | 25.3 ±17.5 | 1750 ±951 | 81.5 ±57.2 | 536.9 ±308.0 |
| Non-current smokers | ||||||||||
| All (88/58) | 5.3 ±3.4 | 3.6 ±2.2** | 139 ±35.2 | 3.9 ±1.9*** | 13.4 ±8.4 | |||||
| Male (38/28) | 5.7 ±2.8 | 3.2 ±1.8 | 118±28.3 | 2.9 ±1.4 | 8.7 ±3.8 | |||||
| Female (50/30) | 4.9 ±3.8 | 4.0 ±2.4 | 154±32.3 | 4.8 ±1.8 | 17.0 ±9.1 | |||||
Measures taken from plasma collected 240 min following the oral administration of deuterated nicotine (D2-nicotine) and analyzed by LC/MS/MS. Values are expressed as means ± standard deviation in pico-moles/ml. trans 3′-hydroxycotinine (3-OHcotinine).
Number of subjects with measures of D2-nicotine, D2-nicotine-glucuronide, D2-cotinine, D2-trans 3′-hydroxycotinine, D0-nicotine-glucuronide, D0-nicotine, D0-cotinine, and D0-trans 3′-hydroxycotinine, includes subjects without genotypes who were not further analyzed.
Number of subjects with measures of D2-cotinine-glucuronide, and D0-cotinine-glucuronide, includes subjects without genotypes who were not further analyzed.
Current smokers includes all subjects with mean undeuterated cotinine > 2 ng/ml, excluding one subject using the nicotine patch.
males vs. females, p = 0.45 corrected for weight
current smokers vs. non-current smokers, p = 0.09
current smokers vs. non-current smokers, p = 0.004