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Prodrug screening using hiPSC-derived neurons
| Prodrug | Inhibition |
|---|---|
| 1' | cytotoxic at 150 µMa |
| 2' | partial inhibition at 300 µM |
| 3a' | EC50 = 374 µM |
| 3b' | EC50 = 209 µM |
| 3c' | EC50 = 198 µM |
| 3d' | EC50 = 572 µM |
| 4a' | cytotoxic at 1 mMa |
| 4b' | cytotoxic at 1 mMa |
| 4d' | EC50 > 1 mM |
No inhibition was observed up to the cytotoxic concentration examined.
