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. Author manuscript; available in PMC: 2015 Jan 7.
Published in final edited form as: Circulation. 2013 Oct 20;129(1):77–86. doi: 10.1161/CIRCULATIONAHA.113.003625

Table 2.

Multivariable-adjusted hazard ratios of CVD events for any CAC and CAC 100 by dyslipidemia category

CAC>0 vs CAC=0 CAC≥100 vs CAC=0
Model 1 Model 2 Model 3 Model 1 Model 2 Model 3
# Lipid Abnormalities
 0 LA (N=1,975) 5.87 (3.59–9.59) 2.88 (1.68–4.94) 2.32 (1.30–4.15) 9.28 (5.56–15.49) 4.31 (2.39–7.77) 3.27 (1.73–6.19)
P<0.0001 P=0.0001 P=0.005 P<0.0001 P<0.0001 P=0.0003
 1 LA (N=2,021) 6.68 (4.19–10.66) 4.65 (2.82–7.67) 3.96 (2.39–6.57) 10.66 (6.57–17.32) 7.51 (4.35–12.96) 5.80 (3.32–10.16)
P<0.0001 P<0.0001 P<0.0001 P<0.0001 P<0.0001 P<0.0001
 2 LA (N=1,208) 4.24 (2.51–7.16) 2.36 (1.34–4.15) 1.95 (1.10–3.47) 6.65 (3.84–11.49) 3.40 (1.84–6.31) 2.74 (1.46–5.13)
P<0.0001 P=0.003 P=0.02 P<0.0001 P=0.0001 P=0.002
 3 LA (N=330) 3.57 (1.54–8.28) 2.59 (1.07–6.30) 2.45 (0.98–6.13) 4.65 (1.86–11.67) 3.28 (1.18–9.17) 3.21 (1.18–8.73)
P=0.003 P=0.04 P=0.06 P=0.001 P=0.02 P=0.02
TC/HDL-C Quartiles
 1st Quartile (N=1,380) 7.83 (4.06–15.11) 3.80 (1.88–7.66) 3.23 (1.52–6.85) 13.58 (6.87–26.82) 6.16 (2.91–13.04) 5.11 (2.28–11.46)
P<0.0001 P=0.0002 P=0.002 P<0.0001 P<0.0001 P=0.0001
 2nd Quartile (N=1,385) 4.11 (2.48–6.80) 2.45 (1.41–4.26) 2.29 (1.29–4.06) 6.03 (3.51–10.37) 3.34 (1.79–6.25) 3.08 (1.61–5.90)
P<0.0001 P=0.002 P=0.005 P<0.001 P=0.0002 P=0.0007
 3rd Quartile (N=1,386) 5.13 (3.02–8.70) 3.20 (1.80–5.68) 2.23 (1.24–4.02) 7.74 (4.44–13.50) 4.40 (2.32–8.35) 2.66 (1.36–5.21)
P<0.0001 P=0.0001 P=0.008 P<0.0001 P<0.0001 P=0.004
 4th Quartile (N=1,383) 5.30 (3.18–8.84) 3.79 (2.21–6.49) 3.11 (1.81–5.35) 8.16 (4.82–13.80) 5.98 (3.36–10.63) 4.69 (2.62–8.37)
P<0.0001 P<0.0001 P<0.0001 P<0.0001 P<0.0001 P<0.0001

Hazard ratios are for the presence of CAC/high CAC by increasing LA; the reference group is CAC=0 within each LA category.

Model 1: unadjusted; Model 2: adjusted for age, sex, ethnicity, education, and MESA site, and; Model 3: adjusted for Model 2 variables plus hypertension, diabetes mellitus, smoking, body mass index, and family history. LA = lipid abnormality; CVD = atherosclerotic cardiovascular disease; CAC = coronary artery calcium. CVD events included myocardial infarction, angina resulting in revascularization, resuscitated cardiac arrest, stroke, cardiovascular death.