Table 1.

Target genes identified as modulators of CDDO-Me efficacy in melanoma cells.

Top 20 genes (siRNAs significantly potentate CDDO-Me in A375 cells	Description	p- Value (1 × 10−4)	Fold Changes
GNPAT	Glyceronephosphate O-acyltransferase	2.82	7.48
SUMO1	SMT3 suppressor of inif two 3 homolog 1 (S. cerevisiae)	5.74	4.23
HOXC9	Homeabox C9	1.02	3.49
SPINT2	Serine peptidase inhibitor. Kunitz type, 2	1.24	3.32
HLCS	Holocarboxylase synthelase	5.77	3.30
GMPR	Guanosine monophosphate reductase	4.67	3.08
FLII	Friend leukemia virus integration 1	3.61	3.07
SSX1	Synovial sarcoma, X breakpoint 1	2.89	2.99
FOXK2	Forkhead box- K2	3.68	2.33
ATP2A2	ATPaxe, Ca2- Iransporimg cardiac, muscle, slow switch 2	3.00	2.31
PDCD61P	Programmed cell death 6 interacting protein	0.781	2.07
ITGAX	Itegrin, alpha X (complement component 3 receptor & subunit)	2,02	1.94
IRX4	Iroquois homeobox 4	4.99	1.87
RBPSUIIL	Recombination signal binding protein for immunoglobulin kappa J region-like	0.502	1.76
KIF5A	Kinesin family member 5A	3.81	1.72
NKX2-8	NK2 homoebox 8	5.49	1.54
UPP1	Uridine, phosphorylase 1	4.52	1.52
SETDB1	SET domain, bifurcated 1	2.70	1.48
SLX1	SLX1 homeobax 1	4.39	1.38
II2AFY	II2A histone family, member Y	4 63	1.31

Top general molecular and cellular function for 35 genes identify by siRNA screen	IPAp-Value	Number of identified genes
Cell death	1.49 × 10−3–4.71 × 10−2	5
Cell niLiiphalugv	1.49 × 10−3–3.95 × 10−2	3
Cellular assembly and organization	1.49 × 10−3–3.37 × 10−2	4
Cellular growth und. prolifeiiition	1.49 × 10−3–4.66 × 10−2	4
DNA repication and repair	1.49 × 10−3–2.98 × 10−2	1

Top interaction signaling networks for 35 genes identify by siRNA screen	IPA Score	Number of identified genes
Cell development, cell growth and proliferation	11	15
Developmental disorder
Organismal development	2~3	3
Nervous system development, and function
Tissue morphology
Reproductive system development and function
Visual system development and function
Metabilic disease	2	1
Genetic disorder
Lipid metabolism