Table 4.

Adverse Outcomes

	Nitrous Oxide/ B-Vitamins (n=250)	Nitrous Oxide /Placebo (n=250)
Within 3 days after surgery
Nausea and vomiting – no. (%)	3 (1.2%)	13 (5.2%)
Wound infection – no. (%)	3 (1.2%)	4 (1.6%)
Any pulmonary – no. (%) *	5 (2.0%)	4 (1.6%)
Any cardiovascular – no. (%) †	16 (6.4%)	25 (10.0%)
Any renal – no. (%) ‡	5 (2.0%)	4 (1.6%)
Bleeding – no. (%)	20 (8.0%)	14 (5.6%)
Ileus – no. (%)	4 (1.6%)	4 (1.6%)
Within 30 days after surgery
Readmission – no. (%)	9 (3.6%)	23 (9.2%)
Wound infection – no. (%)	15 (6%)	18 (7.2%)
Any pulmonary – no. (%) *	3 (1.2 %)	2 (0.8%)
Any cardiovascular – no. (%) †	5 (2.0%)	11 (4.4%)
Any renal – no. (%) ‡	0	0
Bleeding – no. (%)	4 (1.6%)	2 (0.8%)
Ileus – no. (%)	1 (0.4%)	0
Deep venous thrombosis – no. (%)	2 (0.8%)	5 (2.0%)
Death – no. (%)	0	3 (1.2%)

^*Pulmonary complications included respiratory distress, pulmonary oedema, pneumothorax, re-intubation, pneumonia, pleural effusion;

^†Cardiovascular complications included new onset atrial fibrillation, ventricular tachycardia, myocardial infarction, cardiac arrest;

^‡Renal complications included creatinine elevation, acute kidney failure, kidney injury during surgery