Figure 1.
(a) A directed weighted graph bipartite G, with nodes representing a set of miRNAs, M, and set of mRNAs, N, and edges representing the set of interactions, E. Red arrows represent direct inversely correlated interactions, and green arrows represent indirect positively correlated interactions. The shaded area highlights the complete sub-graph or biclique, with edges Et, representing a group of miRNAs that post-transcriptionally downregulate a group of mRNAs. The dashed complete sub-graph, with green edges Ei, represents a group of indirectly upregulated mRNAs (and positively correlated) to every miRNA in the direct biclique. (b) An idealized matrix of all miRNA-mRNA expression correlations across a matched set of samples. The values +1, −1 and 0 represent positive, negative and 0 correlations, respectively.