Table 4.
The top 20 miRNA-mRNA functional modules, in terms of enrichment for Gene Ontology (GO) categories, for the neuroblastoma integrated data set returned by biclustering
| GO category | n | S | P-value | miRNA cluster/family | n | N | P-value |
|---|---|---|---|---|---|---|---|
| Mitotic cell cycle | 57 | 250 | 2.0e-39 | mir-17 cluster | 3 | 6 | 3.0e-03 |
| M phase of mitotic cell cycle | 18 | 220 | 2.0e-15 | mir-8 family | 2 | 5 | 2.1e-02 |
| Mitotic prometaphase | 11 | 154 | 5.9e-10 | mir-17 family | 5 | 8 | 7.3e-05 |
| Signal transduction | 48 | 250 | 9.6e-10 | mir-200a cluster | 2 | 3 | 1.1e-02 |
| Innate immune response | 24 | 250 | 3.7e-08 | ||||
| Nervous system development | 23 | 250 | 5.9e-08 | mir-135 family | 2 | 2 | 6.5e-03 |
| Cell division | 19 | 250 | 7.0e-08 | mir-17 family | 6 | 8 | 7.6e-06 |
| Platelet activation | 16 | 250 | 8.4e-08 | mir-29 family | 3 | 3 | 7.9e-04 |
| Nucleosome assembly | 12 | 250 | 9.0e-08 | mir-181 family | 2 | 4 | 1.5e-02 |
| DNA replication | 13 | 213 | 9.6e-08 | mir-192 cluster | 2 | 2 | 1.0e-02 |
| Inflammatory response | 15 | 250 | 7.3e-06 | mir-489 cluster | 2 | 2 | 6.5e-03 |
| pre-miRNA processing | 4 | 250 | 9.3e-06 | let-7 family | 8 | 9 | 1.4e-07 |
| Gene silencing by RNA | 6 | 250 | 1.2e-05 | let-7 family | 8 | 9 | 1.4e-07 |
| Collagen fibril organization | 6 | 250 | 1.2e-05 | mir-15 family | 4 | 4 | 1.1e-04 |
| Small GTPase-mediated signal transduction | 16 | 250 | 1.9e-05 | mir-302a cluster | 5 | 5 | 2.0e-03 |
| Microtubule cytoskeleton organization | 7 | 250 | 2.1e-05 | mir-329 family | 2 | 3 | 1.1e-02 |
| Cytokine-mediated signaling pathway | 13 | 250 | 2.0e-05 | mir-8 family | 3 | 5 | 2.1e-03 |
| Cellular response to drug | 5 | 250 | 2.6e-05 | mir-329 family | 2 | 3 | 1.1e-02 |
| Cell adhesion | 22 | 250 | 3.0e-05 | let-7 family | 7 | 9 | 1.3e-06 |
| Nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway | 6 | 250 | 4.1e-05 | mir-302a cluster | 5 | 5 | 6.8e-03 |
Enrichment for miRNA genomic clusters and families in human is also shown were applicable. The number of members found in a category (n), the number total of members in the category (N) and the total number of mRNA (S) are given. See Supplementary Table S3 for full set of results.