Table 5.
The top 20 miRNA functional modules, in terms of enrichment for GO categories, uncovered in the Human Immune Cells data set
| GO category | n | S | P-value | miRNA cluster/family | n | N | P-value |
|---|---|---|---|---|---|---|---|
| Viral transcription | 39 | 198 | 5.1e-45 | mir-320 family | 4 | 4 | 1.1e-04 |
| Viral infectious cycle | 28 | 202 | 2.0e-28 | mir-146 family | 2 | 2 | 6.5e-03 |
| Translational termination | 21 | 199 | 3.4e-20 | mir-181a cluster | 2 | 2 | 5.5e-03 |
| Translational elongation | 21 | 198 | 1.2e-19 | mir-320 family | 4 | 4 | 1.1e-04 |
| Translational initiation | 21 | 196 | 1.1e-17 | mir-320 family | 4 | 4 | 1.1e-04 |
| Respiratory electron transport chain | 18 | 220 | 6.4e-15 | mir-181a cluster | 2 | 2 | 6.5e-03 |
| Intracellular signal transduction | 17 | 176 | 3.2e-08 | ||||
| Axon guidance | 17 | 176 | 3.2e-08 | mir-320 family | 4 | 4 | 1.1e-02 |
| Gene expression | 25 | 221 | 4.3e-07 | mir-181a cluster | 2 | 2 | 6.5e-03 |
| Response to lipopolysaccharide | 10 | 170 | 9.3e-07 | mir-15 family | 3 | 4 | 1.3e-03 |
| Small molecule metabolic process | 31 | 211 | 4.2e-06 | mir-188 cluster | 4 | 7 | 4.6e-04 |
| Inflammatory response | 13 | 182 | 5.0e-06 | mir-17 family | 4 | 8 | 6.6e-04 |
| DNA repair | 14 | 203 | 7.4e-06 | ||||
| Apoptotic process | 22 | 214 | 8.4e-06 | let-7 family | 9 | 9 | 1.5e-08 |
| Prostanoid metabolic process | 4 | 180 | 1.4e-05 | mir-15 family | 3 | 4 | 1.3e-03 |
| Microtubule organizing center organization | 3 | 158 | 2.0e-05 | mir-17 family | 8 | 8 | 6.8e-04 |
| Receptor-mediated endocytosis | 6 | 192 | 2.2e-05 | mir-17 family | 5 | 8 | 7.3e-05 |
| Mammary gland development | 5 | 199 | 2.5e-05 | mir-320 family | 4 | 4 | 1.1e-04 |
| Antigen processing and presentation of peptide or polysaccharide antigen via MHC class II | 4 | 162 | 3.0e-05 | mir-500 family | 2 | 3 | 2.1e-02 |
| Positive regulation of DNA replication | 5 | 175 | 4.5e-05 |
Enrichment for miRNA genomic clusters and families is also shown were applicable. The number of members found in a category (n) and the number of members in the category (N) are given. See Supplementary Table S4 for full set of results.