Table 1.
Endothelial disease relevant genes exposed by association to multiple TFs in HUVEC data
| Symbol | Pathway | Entrez GeneID | Number of disease | Number of TFs |
|---|---|---|---|---|
| NOS3 | Arginine and proline metabolism | 4846 | 140 | 8 |
| PTGS2 | Eicosanoid metabolism | 5743 | 97 | 8 |
| HMOX1 | Heme degradation | 3162 | 56 | 8 |
| ABCA1 | Transport, extracellular; transport, golgi apparatus | 19 | 20 | 9 |
| PTGS1 | Eicosanoid metabolism | 5742 | 12 | 8 |
| LIPG | Triacylglycerol synthesis | 9388 | 9 | 10 |
| ADA | Nucleotides; purine catabolism | 100 | 9 | 9 |
| PDE4D | Nucleotides | 5144 | 9 | 8 |
| PDE4B | Nucleotides | 5142 | 8 | 9 |
| ABCC4 | Transport, extracellular | 10 257 | 7 | 9 |
| PDE3A | Nucleotides | 5139 | 7 | 8 |
| PIK3CG | Inositol phosphate metabolism | 5294 | 7 | 8 |
| SLC12A2 | Transport, extracellular | 6558 | 6 | 9 |
| PAFAH2 | Glycerophospholipid metabolism | 5051 | 4 | 9 |
| GCLM | Glutathione metabolism | 2730 | 3 | 10 |
| MTHFD1L | Folate metabolism | 25 902 | 3 | 10 |
| GALNT2 | O-glycan biosynthesis | 2590 | 3 | 9 |
| PPAP2B | Triacylglycerol synthesis | 8613 | 1 | 10 |
| NNMT | NAD metabolism | 4837 | 1 | 10 |
The 19 Recon1 metabolic genes annotated with endothelial-relevant disease terms in the DisGeNET database (32) and having an active TSS mark (H3K4me3) with putative binding of at least 8 TFs from ChIP-Seq HUVEC studies (see ‘Materials and Methods’ section for details) are presented.