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. 2013 Nov 13;42(3):2003–2014. doi: 10.1093/nar/gkt1071

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© The Author(s) 2013. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 8. — A model for Nur-dependent inverse regulation of sodF and sodN. This model describes that the small processed sodF RNA negatively regulates the translation and stability of sodN mRNA, enabling the antagonistic regulation of sodN and sodF genes through nickel-specific Nur. Under nickel-limited conditions, Nur without nickel loses its binding activity to sodF promoter. Induction of sodF gene transcription ensues, producing full length sodF mRNA, from which a 90 nt-long 3′UTR segment that contains anti-sodN sequence of 19 nt can be cleaved off to function as a stable small regulatory RNA (s-SodF). The s-SodF RNA is able to form perfect base pairing with the 5′-end segment of sodN mRNA by up to 18 bp. The base-pairing can inhibit translation by occluding ribosome binding, and facilitates degradation of sodN mRNA, resulting in rapid decrease in the production of Ni-SOD.