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. 2013 Oct 28;42(3):1671–1683. doi: 10.1093/nar/gkt975

Figure 2.

Figure 2.

MUS81-EME1 incision on DNA substrates with 5′-end labeling on the leading strand. (A) Psoralen ICL-damaged substrates. (B) Undamaged structures. Titration of purified MUS81-EME1 (3 nM, 6 nM and 12 nM) on DNA substrates shown on the top of each gel. The schematic appearance of the products after incision was shown on the right. Letter P with a circle indicates γ-32P labeling by T4 polynucleotide kinase. Asterisk (74 nt) indicates a decayed and uncross-linked species. Arrows point to the incision sites and corresponding incision products.