Figure 2.

(A) Arm abundances of 5′-isomiRs from human miRNA hairpins conserved in mammal. The numbers of 5′-isomiR reads and arm abundances were derived from human psoriasis data. Dominant 5′-isomiRs derived from the 3p or 5p arms of miRNA hairpins are indicated in blue and orange, respectively. The solid line separates miRNA hairpins with 5′-isomiRs having arm abundances >10% from that <10%, and the dashed line indicates 5′-isomiRs with greater arm abundances than their major miRNAs. (B) The distribution of miRNAs with human 5′-isomiRs conserved in mammal over their arm abundances. The same color scheme as in (A) is used, showing that hairpins with dominant 5′-isomiRs having arm abundances >10% (the right side of the red line) appear more often on the 3p arms than on the 5p arms.