Table 2.

The top 10 most abundant 5′-isomiRs in human skin

miRNA family	Seed	Arm	Ranka	No. of 5′-isomiR reads	Arm abundance
hsa-miR-203	GAAAUGU	3p	8	8,774,451	45.5
hsa-miR-140	CCACAGG	3p	37	1,072,944	39.5
hsa-miR-126	GUACCGU	3p	54	776,502	13.8
hsa-miR-199b	ACAGUAG	3p	55	724,009	27.0
hsa-miR-101	UACAGUA	3p	57	662,855	27.3
hsa-miR-10a	CCCUGUA	5p	59	661,921	22.7
hsa-miR-143	UGAGAUG	3p	69	619,911	1.8
hsa-miR-378a	UGGACUU	3p	71	402,197	6.0
hsa-miR-29a	UAGCACC	3p	77	334,605	18.1
hsa-let-7a	AGGUAGU	5p	89	269,329	0.6

The arm abundance of a 5′-isomiR is the percentage of all reads mapped to one arm that represents the 5′-isomiR. Seed region represents the range from 2 nt to 8 nt of a 5′-isomiR sequence.

^aRank of the 5′-isomiR among all miRNAs including major miRNAs, determined by the number of sequencing reads.